Since its inception in 1981, nearly 10000 Alumni have graduated from the portals of the Sri Sathya Sai University. These Alumni, while being professionally engaged in different parts of the world, continue to maintain their link with the University and are contributing substantially to the society in which they live.  The Alumni participate in various service activites in the field of Integral Education, Medicine, Village Upliftment (Grama Seva) and other areas.

Some of the areas in which these alumni are engaged include academics, doctors, nurses, paramedical areas, engineers, scientists, Indian Administrative Services, lawyers, chartered accountants, businessmen, management professionals, artists, musicians, dancers, agriculturists, consultants, pilots, state and central government employees, armed forces, merchant navy and even home makers. 
 
A sample of the organisations/institutions where the alumni of the University are employed include Indian Institute of Sciences, Indian Institutes of Technology, Indian Institutes of Management, Government of India, Tata Institute of Fundamental Research, Raman Research Institute, Indian Institute of Astrophysics in India. Some of the overseas institutions where they are professionally engaged are : University of Florida, University of Missouri, University Of California, Johns Hopkins, Arizona State University, University of South Mississippi, University of Texas, University of Kentucky, Texas Tech University, The Pennsylvania State University, Northwestern University, Florida Institute of Technology, University of Minnesota, University of Tennessee, The Scripps Research Institute, Massachussets Institute of Technology, University of Kansas, University of Edinburgh Management School, University of Glasgow, University of Nottingham, Karolinska Instituite, Macquarie University, UNIDO.

Some of the business organisations where the students are in senior positions are HDFC Bank, Barclays Bank, Citibank, Standard Chartered Bank, ABN Amro Bank, HSBC Bank, ICICI Bank, Bank of America, Oracle, Microsoft, GE, HP, Accenture, TCS, Infosys, Wipro, Dun & Bradstreet, Siemens, Philips, TVS Motors, L&T, Reliance, the Tata group companies and some public sector organisations. Among the overseas organisations, students are employed include Walmart, Canarys, SAP America Inc., Intel Corporation, Lucent Technologies, Citigroup, Nortel, PricewaterhouseCoopers, Microsoft, IBM, Ernst & Young LLP, McKinsey & Company, Perot Systems, Sun Microsystems Inc, Cognizant Technology Solutions, Symantec, Reuters, Motorola and many others.
 
Some of them have also been successful entrepreneurs and have created job opportunities for the lesser privileged and even for people in the rural areas. A case in point is a rural BPO, one of the first of its kind started by two alumni of the University in Puttaparthi called SAI SEVA (Serve And Inspire Simple Employment for Village Advancement). A few of these students are also a part of the various institutions run by the Sri Sathya Sai Central Trust which includes the University and other sister institutions; and the Sri Sathya Sai Medical Trust which includes the Sri Sathya Sai General and Super Specialty Hospitals.